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hello all today i'm going to talk about

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the minimization of the bacterial

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ribosome

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comparative sequence analysis of the

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ribosomes from different organisms from

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the williams lab has shown that the

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ribosome being the largest rna protein

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complex is also a molecular fossil which

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means that it records its history in its

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structure over time

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what it means what it also means is that

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the proteins at the heart of the

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ribosome are ancient and unstructured

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while the ones on the outside are recent

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and more globular

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using this premise i am working with the

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e coli bacterial ribosome and designing

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a platform which will enable us to

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reduce the proteome of the ribosome and

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structurally as well as functionally

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analyze the intermediates